The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …
tuberculosis remains out of control in several parts of the world including Africa and Asia …
Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates …
Background The continued advance of antibiotic resistance threatens the treatment and
control of many infectious diseases. This is exemplified by the largest global outbreak of …
control of many infectious diseases. This is exemplified by the largest global outbreak of …
The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and …
Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was
published in 2017, which comprehensively reviewed and provided recommendations on …
published in 2017, which comprehensively reviewed and provided recommendations on …
Isoniazid-resistant tuberculosis: a cause for concern?
The drug isoniazid (INH) is a key component of global tuberculosis (TB) control
programmes. It is estimated, however, that 16.1% of TB disease cases in the former Soviet …
programmes. It is estimated, however, that 16.1% of TB disease cases in the former Soviet …
Data for action: collection and use of local data to end tuberculosis
Accelerating progress in the fight against tuberculosis will require a drastic shift from a
strategy focused on control to one focused on elimination. Successful disease elimination …
strategy focused on control to one focused on elimination. Successful disease elimination …
The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy
Background Combination therapy is one of the most effective tools for limiting the
emergence of drug resistance in pathogens. Despite the widespread adoption of …
emergence of drug resistance in pathogens. Despite the widespread adoption of …
Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy
Drug-resistant tuberculosis is a growing threat to global public health. Recent efforts to
understand the evolution of drug resistance have shown that changes in drug–target …
understand the evolution of drug resistance have shown that changes in drug–target …
Development of new therapeutics to meet the current challenge of drug resistant tuberculosis
Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/morbidity
globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant …
globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant …
Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index
S Wasserman, G Meintjes… - Expert review of anti …, 2016 - Taylor & Francis
Introduction: Linezolid is an oxazolidinone with potent activity against M tuberculosis, and
improves culture conversion and cure rates when added to treatment regimens for drug …
improves culture conversion and cure rates when added to treatment regimens for drug …