Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in
response to changes in perfusion pressure. Due to the challenges of measuring intracranial …

Acute stroke is associated with high morbidity and mortality. In the last decades, new
therapies have been investigated with the aim of improving clinical outcomes in the acute …

The population is ageing worldwide, thus increasing the burden of common age-related
disorders to the individual, society and economy. Cerebrovascular diseases (stroke …

Cerebral hemodynamics, eg, cerebral blood flow, can be measured and quantified using
many different methods, with transcranial Doppler ultrasound (TCD) being one of the most …

Cerebral autoregulation is a complex mechanism that serves to keep cerebral blood flow
relatively constant within a wide range of cerebral perfusion pressures. The mean flow index …

Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility.
In an international, multi-center study, we evaluated the influence of multiple analytical …

Instantaneous arterial pressure-flow (or velocity) relationships indicate the existence of a
cerebral critical closing pressure (CrCP), with the slope of the relationship expressed by the …

Cerebral autoregulation refers to the physiological mechanism that aims to maintain blood
flow to the brain approximately constant when blood pressure changes. Impairment of this …

We tested the influence of blood pressure variability on the reproducibility of dynamic
cerebral autoregulation (DCA) estimates. Data were analyzed from the 2nd CARNet …