Here, we present the main features of human acid sphingomyelinase (ASM), its
biosynthesis, processing and intracellular trafficking, its structure, its broad substrate …

BACKGROUND Chemotherapy-associated ovarian damage (CAOD) is one of the most
feared short-and long-term side effects of anticancer treatment in premenopausal women …

Simple Summary Sphingolipids, which are important cell membrane components, have
critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral …

Sphingolipids are both structural molecules that are essential for cell architecture and
second messengers that are involved in numerous cell functions. Ceramide is the central …

Recent trends indicate a concerning increase in early-onset atherosclerotic cardiovascular
disease (ASCVD) among younger individuals (age< 55 in men and< 65 in women). These …

Traumatic brain injury (TBI) broadly degrades the normal function of the brain after a bump,
blow, or jolt to the head. TBI leads to the aggravation of pre-existing brain dysfunction and …

The present study was to evaluate the chemo-photodynamic synergistic antitumor effect of
FA-BSP-SA/TPGS micelles loaded with doxorubicin (Dox) and Zinc phthalocyanine (ZnPc) …

目的分析黄芪桂枝五物汤加味泡洗包在乳腺癌患者紫杉类药物相关周围神经毒性中的临床疗效.
方法采用便利抽样法, 选取2021 年1 月至2021 年12 月中国医学科学院北京协和医学院肿瘤 …

Atherosclerotic cardiovascular disease (ASCVD) has classically been associated with
increasing age. However, despite advancements in the primary prevention of ASCVD, the …

Metabolomic profiling is a novel technique to identify anthracycline-induced cardiotoxicity
(CTX). Higher physical activity levels may mitigate this damage. Therefore, the primary …