Transition metals occupy an essential niche in biological systems. Their electrostatic
properties stabilize substrates or reaction intermediates in the active sites of enzymes, and …

Lactoferrin is an abundant iron-binding protein in milk. This 80 kDa bilobal glycoprotein is
also present in several other secreted bodily fluids, as well as in the secondary granules of …

Iron is indispensable for the growth, development and well-being of almost all living
organisms. Biological systems from bacteria, fungi and plants to humans have evolved …

Iron is essential to nearly all life forms on Earth, required for the proper function of enzymes
involved in, for example, respiration, photosynthesis, the tricarboxylic acid cycle, nitrogen …

Iron sequestration provides an innate defense, termed nutritional immunity, leading
pathogens to scavenge iron from hosts. Although the molecular basis of this battle for iron is …

Paclitaxel (PTX) remains a cornerstone in the treatment of locally advanced and metastatic
lung cancer. To improve its therapeutic indices against lung cancer, novel redox-sensitive …

We describe a complete implementation of Martini 2 and Martini 3 in the OpenMM molecular
dynamics software package. Martini is a widely used coarse-grained force field with …

Dps proteins are the structural relatives of bacterioferritins and ferritins ubiquitously present
in the bacterial and archaeal kingdoms. The ball-shaped enzymes play important roles in …

Two pathogenic species within the genus N eisseria cause the diseases gonorrhoea and
meningitis. While vaccines are available to protect against four N. meningitidis serogroups …

Acinetobacter baumannii is a human bacterial pathogen of increasing concern in clinical
settings due to the emergence of antibiotic resistant strains and the lack of effective …