Cheminformatics in natural product‐based drug discovery

Y Chen, J Kirchmair - Molecular Informatics, 2020 - Wiley Online Library
This review seeks to provide a timely survey of the scope and limitations of cheminformatics
methods in natural product‐based drug discovery. Following an overview of data resources …

Anti-inflammatory and antimicrobial volatile oils: Fennel and cumin inhibit neutrophilic inflammation via regulating calcium and MAPKs

M Korinek, H Handoussa, YH Tsai, YY Chen… - Frontiers in …, 2021 - frontiersin.org
Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD),
acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global …

Anti-Allergic, Anti-Inflammatory, and Anti-Hyperglycemic Activity of Chasmanthe aethiopica Leaf Extract and Its Profiling Using LC/MS and GLC/MS

IM Ayoub, M Korinek, M El-Shazly, B Wetterauer… - Plants, 2021 - mdpi.com
This study aims to comprehensively explore the phytoconstituents as well as investigate the
different biological activities of Chasmanthe aethiopica (Iridaceae) for the first time …

Chemical space of naturally occurring compounds

FI Saldívar-González, BA Pilón-Jiménez… - Physical Sciences …, 2019 - degruyter.com
The chemical space of naturally occurring compounds is vast and diverse. Other than
biologics, naturally occurring small molecules include a large variety of compounds covering …

Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological Activities

O Mykhailenko, M Korinek, L Ivanauskas, I Bezruk… - Molecules, 2020 - mdpi.com
The major groups of antioxidant compounds (isoflavonoids, xanthones, hydroxycinnamic
acids) in the rhizome methanol extracts of four Ukrainian Iris sp.(Iris pallida, Iris hungarica …

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity …

SS Ebada, NA Al-Jawabri, FS Youssef, DH El-Kashef… - RSC …, 2020 - pubs.rsc.org
On Wednesday 11th March, 2020, the world health organization (WHO) announced novel
coronavirus (COVID-19, also called SARS-CoV-2) as a pandemic. Due to time shortage and …

In vitro anti-allergic activity of Moringa oleifera Lam. extracts and their isolated compounds

NZ Abd Rani, E Kumolosasi, M Jasamai… - … and alternative medicine, 2019 - Springer
Abstract Background Moringa oleifera Lam. is a commonly used plant in herbal medicine
and has various reported bioactivities such as antioxidant, antimicrobial, anticancer and …

Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

AA Thabet, FS Youssef, M Korinek, FR Chang… - … and alternative medicine, 2018 - Springer
Abstract Background Brachychiton rupestris and Brachychiton discolor (Malvaceae) are
ornamental trees native to Australia. Some members of Brachychiton and its highly related …

Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis

HP Lee, W Choi, KW Kwon, L You, L Rahmawati… - Plants, 2022 - mdpi.com
Grewia tomentosa Juss. is a deciduous shrub that mainly grows in Asia. Despite studies of
other Grewia species for treatment of various diseases, Grewia tomentosa Juss. has not …

Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts

O Mykhailenko, V Petrikaite, M Korinek, FR Chang… - Molecules, 2021 - mdpi.com
Crocus sativus L.(saffron) has been traditionally used as a food coloring or flavoring agent,
but recent research has shown its potent pharmacological activity to tackle several health …