Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …

The pancreatic islet displays diverse patterns of endocrine cell arrangement. The prototypic
islet, with insulin-secreting β-cells forming the core surrounded by other endocrine cells in …

The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then
throughout the embryo to establish circulatory networks that further acquire organ-specific …

The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or
causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Every biological trait requires both a proximate and evolutionary explanation. The field of
vascular biology is focused primarily on proximate mechanisms in health and disease …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Bronchopulmonary dysplasia and emphysema are significant global health problems at the
extreme stages of life. Both are characterized by arrested alveolar development or loss of …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

We show that transplantation of adult bone marrow–derived cells expressing c-kit reduces
hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although …