Multicomponent reactions have become increasingly popular as tools for the rapid
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …

This review highlights a number of additives that can be used to make asymmetric reactions
perfect. Without changing other reaction conditions, simply adding additives can lead to …

Chiral molecules containing asymmetric carbon centers bonded with nitrogen are ubiquitous
in nature and also form important structural fragments in both natural and man-made …

The catalysis by primary and secondary amines of electrophilic substitution reactions in the
R-position of carbonyl compounds and related reactions via enamine intermediates is called …

The substitution of primary or secondary alcohols with nucleophiles mediated by a redox
combination of a trialkylor triarylphosphine and a dialkyl azodicarboxylate is popularly …

Abstract The legacy of Gilbert Newton Lewis (1875–1946) pervades the lexicon of chemical
bonding and reactivity. The power of his concept of donor–acceptor bonding is evident in the …

Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well‐
established and powerful synthetic tool for the chemo‐and enantioselective functionalization …

After an initial period of validating asymmetric organocatalysis by using a wide range of
important model reactions that constitute the essential tools of organic synthesis, the time …

Binaphthol-derived monophosphoric acids have been designed as novel chiral Brønsted-
acid catalysts. The chiral phosphoric acids thus developed function as efficient …

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis.
Recent years have witnessed increasing interest towards the use of highly active and …