Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products,
although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from …

Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …

Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To
gain a more comprehensive understanding of what causes AD and its subsequent …

Epidemiological and basic science evidence suggest a possible shared pathophysiology
between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). It has even been …

Background: Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disorder with interrelated molecular, physiological, anatomical …

Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …

Alzheimer's disease (AD), the most common neurodegenerative disorder associated with
dementia, is typified by the pathological accumulation of amyloid Aβ peptides and …

Age is a common risk factor for Alzheimer's disease (AD) and age-related macular
degeneration (AMD). Because of the increasing age of the population, these two age-related …

Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular
neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary …