Fungal biofilm infections have become increasingly recognised as a significant clinical
problem. One of the major reasons behind this is the impact that these have upon treatment …

Candida commonly adheres to implanted medical devices, growing as a resilient biofilm
capable of withstanding extraordinarily high antifungal concentrations. As currently available …

Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in
several cellular processes. The calcineurin signaling cascade is one of the major pathways …

The burden of human disease associated with fungal infections is generally
underappreciated, with estimates indicating as many as 150 million persons infected …

Most of the fungal species that infect humans can grow in more than one morphological form
but only a subset of pathogens produce filamentous hyphae during the infection process …

In recent years, the emergence of fungal resistance has become frequent, partly due to the
widespread clinical use of fluconazole, which is minimally toxic and effective in the …

In this era of efficacious antiretroviral therapy and consequent immune reconstitution,
oropharyngeal and esophageal candidiasis (OPC and OEC) still remain two clinically …

Many pathogenic fungi are dimorphic and switch between yeast and filamentous states. This
switch alters host-microbe interactions and is critical for pathogenicity. However, in …

Increases in the incidence and mortality due to the major invasive fungal infections such as
aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida …

Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …