Pre-metastatic niches: organ-specific homes for metastases
It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …
tumour cells, but are instead selectively and actively modified by the primary tumour before …
[HTML][HTML] Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries
P Wongtrakoongate - World journal of stem cells, 2015 - ncbi.nlm.nih.gov
Recent advances in stem cell biology have shed light on how normal stem and progenitor
cells can evolve to acquire malignant characteristics during tumorigenesis. The cancer …
cells can evolve to acquire malignant characteristics during tumorigenesis. The cancer …
Influencing the tumor microenvironment: a phase II study of copper depletion using tetrathiomolybdate in patients with breast cancer at high risk for recurrence and in …
N Chan, A Willis, N Kornhauser, MM Ward, SB Lee… - Clinical Cancer …, 2017 - AACR
Purpose: Bone marrow–derived progenitor cells, including VEGFR2+ endothelial progenitor
cells (EPCs) and copper-dependent pathways, model the tumor microenvironment. We …
cells (EPCs) and copper-dependent pathways, model the tumor microenvironment. We …
[HTML][HTML] Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer
YL Liu, CL Bager, N Willumsen, D Ramchandani… - NPJ breast …, 2021 - nature.com
Tetrathiomolybdate (TM) is a novel, copper-depleting compound associated with promising
survival in a phase II study of patients with high-risk and triple-negative breast cancer. We …
survival in a phase II study of patients with high-risk and triple-negative breast cancer. We …
A Single‐Arm, Phase II Study of Apatinib in Refractory Metastatic Colorectal Cancer
X Chen, T Qiu, Y Zhu, J Sun, P Li, B Wang, P Lin… - The …, 2019 - academic.oup.com
Abstract Lessons Learned Patients with metastatic colorectal cancer with good performance
status or no liver metastasis could benefit from apatinib. Circulating tumor DNA abundance …
status or no liver metastasis could benefit from apatinib. Circulating tumor DNA abundance …
VEGF 相关信号通路在血管新生中的研究进展
向本旭， 刘婷婷， 孙芳玲， 艾厚喜， 王文 - 中国比较医学杂志, 2015 - cqvip.com
组织器官在生理或病理状态下, 受到促血管生成因子的刺激, 引发生血管新生. VEGF, Notch,
Wnt/β-catenin, Ang1 (2)/tie2, PI3K-AKT 等多个信号通路参与到该过程, 对血管新生的各个阶段 …
Wnt/β-catenin, Ang1 (2)/tie2, PI3K-AKT 等多个信号通路参与到该过程, 对血管新生的各个阶段 …
[HTML][HTML] Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
S Jain, J Cohen, MM Ward, N Kornhauser, E Chuang… - Annals of oncology, 2013 - Elsevier
Background Bone marrow-derived endothelial progenitor cells (EPCs) are critical for
metastatic progression. This study explores the effect of tetrathiomolybdate (TM), an anti …
metastatic progression. This study explores the effect of tetrathiomolybdate (TM), an anti …
Targeting the vascular endothelial growth factor receptor-1 by the monoclonal antibody D16F7 to increase the activity of immune checkpoint inhibitors against …
PM Lacal, MG Atzori, F Ruffini, M Scimeca… - Pharmacological …, 2020 - Elsevier
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a membrane receptor for
VEGF-A, placenta growth factor (PlGF) and VEGF-B that plays a crucial role in melanoma …
VEGF-A, placenta growth factor (PlGF) and VEGF-B that plays a crucial role in melanoma …
[HTML][HTML] VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells
Endothelial colony forming cells (ECFCs) represent a population of truly endothelial
precursors that promote the angiogenic switch in solid tumors, such as breast cancer (BC) …
precursors that promote the angiogenic switch in solid tumors, such as breast cancer (BC) …
[HTML][HTML] Metronomic anti-cancer therapy: A multimodal therapy governed by the tumor microenvironment
Simple Summary Metronomic chemotherapy with different mechanisms of action against
cancer cells and their microenvironment represents an exceptional holistic cancer treatment …
cancer cells and their microenvironment represents an exceptional holistic cancer treatment …