The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human
cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of …

B-cell non-Hodgkin's lymphoma comprises biologically and clinically distinct diseases the
pathogenesis of which is associated with genetic lesions affecting oncogenes and tumour …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

Photothermal therapy (PTT) is an emerging therapeutic strategy in the treatment of cancer;
however, a critical challenge remains in the rational design of synergistic nanoparticles as a …