Metabolic coordination of T cell quiescence and activation
NM Chapman, MR Boothby, H Chi - Nature reviews immunology, 2020 - nature.com
Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
[HTML][HTML] CD38: an immunomodulatory molecule in inflammation and autoimmunity
ZL Piedra-Quintero, Z Wilson, P Nava… - Frontiers in …, 2020 - frontiersin.org
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis
Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that essentially
support germinal center responses where high-affinity and long-lived humoral immunity is …
support germinal center responses where high-affinity and long-lived humoral immunity is …
[HTML][HTML] The P2X7 receptor in infection and inflammation
Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …
[HTML][HTML] Evolving concepts in NAD+ metabolism
CCS Chini, JD Zeidler, S Kashyap, G Warner, EN Chini - Cell metabolism, 2021 - cell.com
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
[HTML][HTML] Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection
In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …
but further improvements probably depend upon development of a broadly protective …
[HTML][HTML] The relationship between nutrition and the immune system
C Munteanu, B Schwartz - Frontiers in nutrition, 2022 - frontiersin.org
Nutrition plays an essential role in the regulation of optimal immunological response, by
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …
that serves as an essential cofactor and substrate for a number of critical cellular processes …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …