Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …

A remarkable characteristic of majority of cancer cells is that, they fail to undergo apoptosis,
which in turn confers them a survival advantage over normal cells. Targeted cancer therapy …

Based on its potent capacity to induce tumor cell death and to abrogate clonogenic survival,
radiotherapy is a key part of multimodal cancer treatment approaches. Numerous clinical …

The potential of gossypol and of its R-(−)-enantiomer (R-(−)-gossypol acetic acid, AT-101),
has been evaluated for treatment of cancer as an independent agent and in combination …

Background Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with
the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC …

Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis
pathways are especially critical as they confer resistance to conventional anti-cancer …

In this study, we investigated the role of mitogen-activated protein kinase (MAPK) signaling
pathways in mediation of the protective effects of saffron extract, saffron essential oil …

Malignant gliomas exhibit a high intrinsic resistance against stimuli triggering apoptotic cell
death. HSF1 acts as transcription factor upstream of HSP70 and the HSP70 co-chaperone …

B‐cell lymphoma 2 (Bcl‐2) is a regulator protein involved in apoptosis. In the past few
decades, this protein has been demonstrated to have high efficacy in cancer therapy, and …

Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …