ContextThe efficient sequestration of hemoglobin by the red blood cell membrane and the
presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

Pulmonary hypertension is prevalent in adult patients with sickle cell disease and is strongly
associated with early mortality and markers of hemolysis, in particular, serum lactate …

This review presents evidence for two overlapping yet distinctive clinical types of sickle cell
disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of …

Sickle-cell anaemia is the most common cause of stroke in children, and stroke is one of the
most devastating complications of sickle-cell disease. Overt strokes are typically due to large …

During intravascular hemolysis in human disease, vasomotor tone and organ perfusion may
be impaired by the increased reactivity of cell-free plasma hemoglobin (Hb) with NO. We …

Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a
strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to …

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by microvascular
vaso-occlusion with erythrocytes containing polymerized sickle (S) hemoglobin, erythrocyte …

Erythrocyte glutathione depletion has been linked to hemolysis and oxidative stress.
Glutamine plays an additional antioxidant role through preservation of intracellular …

Endothelial cell adhesion molecules orchestrate the recruitment and binding of inflammatory
cells to vascular endothelium. With endothelial dysfunction and vascular injury, the levels of …