Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative
immunosuppressive drugs and have many clinical applications in various drug …

Advances in maintenance immunosuppression over the past three decades have improved
solid organ transplantation outcomes dramatically. Uninterrupted access to …

Kidney transplantation is the optimal treatment for patients with end stage renal disease
(ESRD) who would otherwise require dialysis. Patients with ESRD are at dramatically …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

The clinical profile of belatacept in kidney transplant recipients was evaluated to determine if
earlier results in the BENEFIT study were sustained at 3 years. BENEFIT is a randomized 3 …

Background: There is no doubt that acute calcineurin inhibitor (CNI) nephrotoxicity exists;
however, chronic CNI nephrotoxicity is questionable at best. Methods: We reviewed the …

Donor-specific HLA antibodies (DSA) have a negative impact on kidney graft survival.
Therefore, we analyzed the occurrence of DSA and antibody-mediated rejection (AMR) in …

Introduction: The mTOR (mechanistic target of rapamycin, formerly known as mammalian
target of rapamycin) kinase is centrally involved in the regulation of cell growth and …

Background Kidney allograft failure is a common cause of end-stage renal disease. We
aimed to develop a dynamic artificial intelligence approach to enhance risk stratification for …