Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023 - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

E Fröhlich - International journal of nanomedicine, 2012 - Taylor & Francis
Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …

[HTML][HTML] Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria

G Fang, W Li, X Shen, JM Perez-Aguilar… - Nature …, 2018 - nature.com
Noble metal-based nanomaterials have shown promise as potential enzyme mimetics, but
the facet effect and underlying molecular mechanisms are largely unknown. Herein, with a …

Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites

Y Li, H Yuan, A von Dem Bussche… - Proceedings of the …, 2013 - National Acad Sciences
Understanding and controlling the interaction of graphene-based materials with cell
membranes is key to the development of graphene-enabled biomedical technologies and to …

Nanoparticles for imaging, sensing, and therapeutic intervention

LK Bogart, G Pourroy, CJ Murphy, V Puntes… - ACS …, 2014 - ACS Publications
Nanoparticles have the potential to contribute to new modalities in molecular imaging and
sensing as well as in therapeutic interventions. In this Nano Focus article, we identify some …

Effect of size and surface charge of gold nanoparticles on their skin permeability: a molecular dynamics study

R Gupta, B Rai - Scientific reports, 2017 - nature.com
Molecular level understanding of permeation of nanoparticles through human skin
establishes the basis for development of novel transdermal drug delivery systems and …

Theoretical and computational investigations of nanoparticle–biomembrane interactions in cellular delivery

H Ding, Y Ma - Small, 2015 - Wiley Online Library
With the rapid development of nanotechnology, nanoparticles have been widely used in
many applications such as phototherapy, cell imaging, and drug/gene delivery. A better …

Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers

RC Van Lehn, PU Atukorale, RP Carney, YS Yang… - Nano …, 2013 - ACS Publications
Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to
nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the …

Reviewing nanoplastic toxicology: It's an interface problem

S Kihara, I Köper, JP Mata, DJ McGillivray - Advances in Colloid and …, 2021 - Elsevier
Multiple international agencies have recently raised environmental and health concerns
regarding plastics in nanoforms (nanoplastics), but there is insufficient knowledge of their …

Shape effect in cellular uptake of PEGylated nanoparticles: comparison between sphere, rod, cube and disk

Y Li, M Kröger, WK Liu - Nanoscale, 2015 - pubs.rsc.org
The size, shape, surface property and material composition of polymer-coated nanoparticles
(NPs) are four important parameters in designing efficient NP-based carriers for targeted …