The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

M Awashra, P Młynarz - Nanoscale Advances, 2023 - pubs.rsc.org
Nowadays, nanomaterials (NMs) are widely present in daily life due to their significant
benefits, as demonstrated by their application in many fields such as biomedicine …

Machine learning-integrated omics for the risk and safety assessment of nanomaterials

F Ahmad, A Mahmood, T Muhmood - Biomaterials science, 2021 - pubs.rsc.org
With the advancement in nanotechnology, we are experiencing transformation in world
order with deep insemination of nanoproducts from basic necessities to advanced …

[HTML][HTML] Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic …

A Schaffert, I Karkossa, E Ueberham… - Environment …, 2022 - Elsevier
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as
phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the …

Progress in toxicogenomics to protect human health

MJ Meier, J Harrill, K Johnson, RS Thomas… - Nature Reviews …, 2024 - nature.com
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …

[HTML][HTML] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation

A Schaffert, L Krieg, J Weiner, R Schlichting… - Environment …, 2021 - Elsevier
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was
reported to cause adverse effects, including disruption of adipocyte differentiation …

The emerging plasticizer alternative DINCH and its metabolite MINCH induce oxidative stress and enhance inflammatory responses in human THP-1 macrophages

A Schaffert, J Arnold, I Karkossa, M Blüher… - Cells, 2021 - mdpi.com
The use of the plasticizer bis (2-ethylhexyl) phthalate (DEHP) and other plasticizers in the
manufacture of plastic products has been restricted due to adverse health outcomes such as …

The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice

T Streidl, I Karkossa, RR Segura Munoz, C Eberl… - Gut …, 2021 - Taylor & Francis
Extibacter muris is a newly described mouse gut bacterium which metabolizes cholic acid
(CA) to deoxycholic acid (DCA) via 7α-dehydroxylation. Although bile acids influence …

[HTML][HTML] A computational view on nanomaterial intrinsic and extrinsic features for nanosafety and sustainability

G Mancardi, A Mikolajczyk, VK Annapoorani, A Bahl… - Materials Today, 2023 - Elsevier
In recent years, an increasing number of diverse Engineered Nano-Materials (ENMs), such
as nanoparticles and nanotubes, have been included in many technological applications …

Influence of size and phase on the biodegradation, excretion, and phytotoxicity persistence of single-layer molybdenum disulfide

W Zou, X Li, C Li, Y Sun, X Zhang, C Jin… - Environmental …, 2020 - ACS Publications
The increasing applications of single-layer molybdenum disulfide (SLMoS2) pose great
potential risks associated with environmental exposure. This study found that metallic-phase …

Bioinformatics and machine learning to support nanomaterial grouping

A Bahl, S Halappanavar, W Wohlleben, P Nymark… - …, 2024 - Taylor & Francis
Nanomaterials (NMs) offer plenty of novel functionalities. Moreover, their physicochemical
properties can be fine-tuned to meet the needs of specific applications, leading to virtually …