Cyclodextrins (CyDs) are extensively used in various fields, and especially have been
widely utilized as pharmaceutical excipients and drug carriers in the pharmaceutical field …

Receptor tyrosine kinases (RTK) are an important family of growth factor and hormone
receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the …

Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive
and is frequently associated with poor clinical outcomes. As a membrane-embedded …

Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms
with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that …

Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1
(CDCP1), by plasmin-like serine proteases induces outside–in signal transduction that …

The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR
is activated by ligand binding, triggering receptor dimerization, activation of kinase activity …

The CUB domain-containing protein-1 (CDCP1) is a transmembrane molecule that has
recently been implicated in cancer progression. In this study we have established a novel …

Tumor metastasis is a complex multistep process by which cells from the primary tumor
invade tissues, move through the vasculature, settle at distant sites and eventually grow to …

Adequate numbers and functional maturity are needed for leukocytes to exhibit a protective
role in host defense. During intrauterine life, the skin immune system has to acquire these …

In the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐
containing protein 1 (CDCP1) has been associated with several cancers and this cell …