Potential use of cyclodextrins as drug carriers and active pharmaceutical ingredients
H Arima, K Motoyama, T Higashi - Chemical and Pharmaceutical …, 2017 - jstage.jst.go.jp
Cyclodextrins (CyDs) are extensively used in various fields, and especially have been
widely utilized as pharmaceutical excipients and drug carriers in the pharmaceutical field …
widely utilized as pharmaceutical excipients and drug carriers in the pharmaceutical field …
Charming neighborhoods on the cell surface: plasma membrane microdomains regulate receptor tyrosine kinase signaling
RCD Santos, C Garay, CN Antonescu - Cellular signalling, 2015 - Elsevier
Receptor tyrosine kinases (RTK) are an important family of growth factor and hormone
receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the …
receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the …
[HTML][HTML] Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer
J Zhang, Q Li, Y Wu, D Wang, L Xu, Y Zhang… - Cell Communication and …, 2019 - Springer
Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive
and is frequently associated with poor clinical outcomes. As a membrane-embedded …
and is frequently associated with poor clinical outcomes. As a membrane-embedded …
[HTML][HTML] Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers
Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms
with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that …
with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that …
In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling
B Casar, I Rimann, H Kato, SJ Shattil, JP Quigley… - Oncogene, 2014 - nature.com
Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1
(CDCP1), by plasmin-like serine proteases induces outside–in signal transduction that …
(CDCP1), by plasmin-like serine proteases induces outside–in signal transduction that …
[HTML][HTML] Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling
MG Sugiyama, AI Brown, J Vega-Lugo… - Nature …, 2023 - nature.com
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR
is activated by ligand binding, triggering receptor dimerization, activation of kinase activity …
is activated by ligand binding, triggering receptor dimerization, activation of kinase activity …
Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells
The CUB domain-containing protein-1 (CDCP1) is a transmembrane molecule that has
recently been implicated in cancer progression. In this study we have established a novel …
recently been implicated in cancer progression. In this study we have established a novel …
Roles of CUB domain‐containing protein 1 signaling in cancer invasion and metastasis
T Uekita, R Sakai - Cancer science, 2011 - Wiley Online Library
Tumor metastasis is a complex multistep process by which cells from the primary tumor
invade tissues, move through the vasculature, settle at distant sites and eventually grow to …
invade tissues, move through the vasculature, settle at distant sites and eventually grow to …
[HTML][HTML] HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells
C Schuster, C Vaculik, C Fiala, S Meindl… - The Journal of …, 2009 - ncbi.nlm.nih.gov
Adequate numbers and functional maturity are needed for leukocytes to exhibit a protective
role in host defense. During intrauterine life, the skin immune system has to acquire these …
role in host defense. During intrauterine life, the skin immune system has to acquire these …
The cell surface glycoprotein CDCP1 in cancer—insights, opportunities, and challenges
A Wortmann, Y He, EI Deryugina, JP Quigley… - IUBMB …, 2009 - Wiley Online Library
In the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐
containing protein 1 (CDCP1) has been associated with several cancers and this cell …
containing protein 1 (CDCP1) has been associated with several cancers and this cell …