Topics in herpesvirus genomics and evolution
DJ McGeoch, FJ Rixon, AJ Davison - Virus research, 2006 - Elsevier
Herpesviruses comprise an abundant, widely distributed group of large DNA viruses of
humans and other vertebrates, and overall are among the most extensively studied large …
humans and other vertebrates, and overall are among the most extensively studied large …
Herpes simplex keratitis
S Kaye, A Choudhary - Progress in retinal and eye research, 2006 - Elsevier
Herpes simplex keratitis (HSK) results from an infection with the herpes simplex virus type 1
(HSV-1) also known as human herpesvirus type 1 (HHV-1). Primary infection may involve an …
(HSV-1) also known as human herpesvirus type 1 (HHV-1). Primary infection may involve an …
Evolution and diversity in human herpes simplex virus genomes
ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …
Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic …
J Nugent, I Birch-Machin, KC Smith… - Journal of …, 2006 - Am Soc Microbiol
ABSTRACT Equid herpesvirus 1 (EHV-1) can cause a wide spectrum of diseases ranging
from inapparent respiratory infection to the induction of abortion and, in extreme cases …
from inapparent respiratory infection to the induction of abortion and, in extreme cases …
A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses
Alphaherpesviruses are widespread in the human population, and include herpes simplex
virus 1 (HSV-1) and 2, and varicella zoster virus (VZV). These viral pathogens cause …
virus 1 (HSV-1) and 2, and varicella zoster virus (VZV). These viral pathogens cause …
Impacts of genome-wide analyses on our understanding of human herpesvirus diversity and evolution
Until fairly recently, genome-wide evolutionary dynamics and within-host diversity were
more commonly examined in the context of small viruses than in the context of large double …
more commonly examined in the context of small viruses than in the context of large double …
Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations
ABSTRACT Herpes simplex virus 1 (HSV-1) is a well-adapted human pathogen that can
invade the peripheral nervous system and persist there as a lifelong latent infection. Despite …
invade the peripheral nervous system and persist there as a lifelong latent infection. Despite …
Inborn errors of anti-viral interferon immunity in humans
V Sancho-Shimizu, RP de Diego, E Jouanguy… - Current opinion in …, 2011 - Elsevier
The three types of interferon (IFNs) are essential for immunity against at least some viruses
in the mouse model of experimental infections, type I IFNs displaying the broadest and …
in the mouse model of experimental infections, type I IFNs displaying the broadest and …
Herpesviruses hijack host exosomes for viral pathogenesis
S Sadeghipour, RA Mathias - Seminars in cell & developmental biology, 2017 - Elsevier
Herpesviruses are remarkable pathogens possessing elaborate mechanisms to seize
various host cellular components for immune evasion, replication, and virion egress. As …
various host cellular components for immune evasion, replication, and virion egress. As …
Targeted DNA mutagenesis for the cure of chronic viral infections
JT Schiffer, M Aubert, ND Weber, E Mintzer… - Journal of …, 2012 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex
virus (HSV) have been incurable to date because effective antiviral therapies target only …
virus (HSV) have been incurable to date because effective antiviral therapies target only …