Immune system dysregulation during spaceflight: potential countermeasures for deep space exploration missions
BE Crucian, A Choukèr, RJ Simpson, S Mehta… - Frontiers in …, 2018 - frontiersin.org
Recent studies have established that dysregulation of the human immune system and the
reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight …
reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight …
[HTML][HTML] Obesity-induced thymic involution and cancer risk
MK Lagou, GS Karagiannis - Seminars in Cancer Biology, 2023 - Elsevier
Declining thymic functions associated either with old age (ie, age-related thymic involution),
or with acute involution as a result of stress, infectious disease, or cytoreductive therapies …
or with acute involution as a result of stress, infectious disease, or cytoreductive therapies …
Testosterone and corticosterone in the mesocorticolimbic system of male rats: effects of gonadectomy and caloric restriction
DJ Tobiansky, AM Korol, C Ma, JE Hamden… - …, 2018 - academic.oup.com
Steroid hormones can modulate motivated behaviors through the mesocorticolimbic system.
Gonadectomy (GDX) is a common method to determine how steroids influence the …
Gonadectomy (GDX) is a common method to determine how steroids influence the …
Sex differences in glucocorticoid responses to shipping stress in Pekin ducks
Some concerns have been raised recently about the assay of corticosterone vs. cortisol in
poultry species. Thus, we tested the hypothesis that ducks secrete both glucocorticoids. First …
poultry species. Thus, we tested the hypothesis that ducks secrete both glucocorticoids. First …
Sex differences in serum glucocorticoid levels and heterophil: lymphocyte ratios in adult pekin ducks (Anas platyrhynchos domesticus)
It is becoming more common for poultry scientists to utilize direct and indirect measures of
stress hormones to monitor bird welfare. However, it has been clear that our understanding …
stress hormones to monitor bird welfare. However, it has been clear that our understanding …
Sucrose consumption alters steroid and dopamine signalling in the female rat brain
Sucrose consumption is associated with type 2 diabetes, cardiovascular disease, and
cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects …
cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects …
Histopathological analysis of tumor microenvironment and angiogenesis in pheochromocytoma
X Gao, Y Yamazaki, A Pecori, Y Tezuka… - Frontiers in …, 2020 - frontiersin.org
Pheochromocytomas (PHEOs) are relatively rare catecholamine-producing tumors derived
from adrenal medulla. Tumor microenvironment (TME) including neoangiogenesis has been …
from adrenal medulla. Tumor microenvironment (TME) including neoangiogenesis has been …
Steroid profiling of glucocorticoids in microdissected mouse brain across development
JE Hamden, KM Gray, M Salehzadeh… - Developmental …, 2021 - Wiley Online Library
Corticosterone is produced by the adrenal glands and also produced locally by other
organs, such as the brain. Local levels of corticosterone in specific brain regions during …
organs, such as the brain. Local levels of corticosterone in specific brain regions during …
Hypergravity disrupts murine intestinal microbiota
C Alauzet, L Cunat, M Wack, A Lozniewski, H Busby… - Scientific Reports, 2019 - nature.com
During spaceflight, organisms are subjected to various physical stressors including
modification of gravity (G) that, associated with lifestyle, could lead to impaired immunity …
modification of gravity (G) that, associated with lifestyle, could lead to impaired immunity …
Regulation of tissue immune responses by local glucocorticoids at epithelial barriers and their impact on interorgan crosstalk
The anti-inflammatory role of extra-adrenal glucocorticoid (GC) synthesis at epithelial
barriers is of increasing interest with regard to the search for alternatives to synthetic …
barriers is of increasing interest with regard to the search for alternatives to synthetic …