Immune system dysregulation during spaceflight: potential countermeasures for deep space exploration missions

BE Crucian, A Choukèr, RJ Simpson, S Mehta… - Frontiers in …, 2018 - frontiersin.org
Recent studies have established that dysregulation of the human immune system and the
reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight …

[HTML][HTML] Obesity-induced thymic involution and cancer risk

MK Lagou, GS Karagiannis - Seminars in Cancer Biology, 2023 - Elsevier
Declining thymic functions associated either with old age (ie, age-related thymic involution),
or with acute involution as a result of stress, infectious disease, or cytoreductive therapies …

Testosterone and corticosterone in the mesocorticolimbic system of male rats: effects of gonadectomy and caloric restriction

DJ Tobiansky, AM Korol, C Ma, JE Hamden… - …, 2018 - academic.oup.com
Steroid hormones can modulate motivated behaviors through the mesocorticolimbic system.
Gonadectomy (GDX) is a common method to determine how steroids influence the …

Sex differences in glucocorticoid responses to shipping stress in Pekin ducks

V Tetel, B Van Wyk, GS Fraley - Poultry Science, 2022 - Elsevier
Some concerns have been raised recently about the assay of corticosterone vs. cortisol in
poultry species. Thus, we tested the hypothesis that ducks secrete both glucocorticoids. First …

Sex differences in serum glucocorticoid levels and heterophil: lymphocyte ratios in adult pekin ducks (Anas platyrhynchos domesticus)

V Tetel, S Tonissen, GS Fraley - General and Comparative Endocrinology, 2022 - Elsevier
It is becoming more common for poultry scientists to utilize direct and indirect measures of
stress hormones to monitor bird welfare. However, it has been clear that our understanding …

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

DJ Tobiansky, GV Kachkovski, RT Enos… - Journal of …, 2020 - joe.bioscientifica.com
Sucrose consumption is associated with type 2 diabetes, cardiovascular disease, and
cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects …

Histopathological analysis of tumor microenvironment and angiogenesis in pheochromocytoma

X Gao, Y Yamazaki, A Pecori, Y Tezuka… - Frontiers in …, 2020 - frontiersin.org
Pheochromocytomas (PHEOs) are relatively rare catecholamine-producing tumors derived
from adrenal medulla. Tumor microenvironment (TME) including neoangiogenesis has been …

Steroid profiling of glucocorticoids in microdissected mouse brain across development

JE Hamden, KM Gray, M Salehzadeh… - Developmental …, 2021 - Wiley Online Library
Corticosterone is produced by the adrenal glands and also produced locally by other
organs, such as the brain. Local levels of corticosterone in specific brain regions during …

Hypergravity disrupts murine intestinal microbiota

C Alauzet, L Cunat, M Wack, A Lozniewski, H Busby… - Scientific Reports, 2019 - nature.com
During spaceflight, organisms are subjected to various physical stressors including
modification of gravity (G) that, associated with lifestyle, could lead to impaired immunity …

Regulation of tissue immune responses by local glucocorticoids at epithelial barriers and their impact on interorgan crosstalk

VM Merk, TS Phan, T Brunner - Frontiers in Immunology, 2021 - frontiersin.org
The anti-inflammatory role of extra-adrenal glucocorticoid (GC) synthesis at epithelial
barriers is of increasing interest with regard to the search for alternatives to synthetic …