Classical and noncanonical functions of miRNAs in cancers
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …
progression of human cancers. The molecular events responsible for the widespread …
Idiopathic pulmonary fibrosis: pathogenesis and management
G Sgalla, B Iovene, M Calvello, M Ori, F Varone… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …
Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis
VJ Craig, L Zhang, JS Hagood… - American journal of …, 2015 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …
Lung development: orchestrating the generation and regeneration of a complex organ
M Herriges, EE Morrisey - Development, 2014 - journals.biologists.com
The respiratory system, which consists of the lungs, trachea and associated vasculature, is
essential for terrestrial life. In recent years, extensive progress has been made in defining …
essential for terrestrial life. In recent years, extensive progress has been made in defining …
MicroRNA epigenetic signatures in human disease
K Piletič, T Kunej - Archives of toxicology, 2016 - Springer
MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …
Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …
Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis
H Ma, X Wu, Y Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …