[HTML][HTML] Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among …
Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin
studies demonstrate high heritability of 60–90%, indicating a predominant role of genetics in …
studies demonstrate high heritability of 60–90%, indicating a predominant role of genetics in …
Model systems and organisms for addressing inter-and intra-species variability in risk assessment
Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …
remains a long-standing challenge in human health risk assessment that is typically …
Combined association of urinary volatile organic compounds with chronic bronchitis and emphysema among adults in NHANES 2011–2014: the mediating role of …
Y Wang, Y Yu, X Zhang, H Zhang, Y Zhang, S Wang… - Chemosphere, 2024 - Elsevier
Evidence on the association of volatile organic compounds (VOCs) with chronic bronchitis
(CB) and emphysema is spare and defective. To evaluate the relationship between urinary …
(CB) and emphysema is spare and defective. To evaluate the relationship between urinary …
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review
S Goodman, G Chappell, KZ Guyton… - … Research/reviews in …, 2022 - Elsevier
Epigenetic alterations, such as changes in DNA methylation, histones/chromatin structure,
nucleosome positioning, and expression of non-coding RNAs, are recognized among key …
nucleosome positioning, and expression of non-coding RNAs, are recognized among key …
[HTML][HTML] Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome
A Nagarajan, K Scoggin, J Gupta, DW Threadgill… - Microbiome, 2023 - Springer
Background The human gut microbiota is a complex community comprised of trillions of
bacteria and is critical for the digestion and absorption of nutrients. Bacterial communities of …
bacteria and is critical for the digestion and absorption of nutrients. Bacterial communities of …
Intra-and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl) guanine adducts following inhalation exposure to 1, 3-butadiene
1, 3-Butadiene is a known carcinogen primarily targeting lymphoid tissues, lung, and liver.
Cytochrome P450 activates butadiene to epoxides which form covalent DNA adducts that …
Cytochrome P450 activates butadiene to epoxides which form covalent DNA adducts that …
[HTML][HTML] An assessment on ethanol-blended gasoline/diesel fuels on cancer risk and mortality
S Mueller, G Dennison, S Liu - International journal of environmental …, 2021 - mdpi.com
Although cancer is traditionally considered a genetic disease, the epigenetic abnormalities,
including DNA hypermethylation, histone deacetylation, and/or microRNA dysregulation …
including DNA hypermethylation, histone deacetylation, and/or microRNA dysregulation …
Integrative analysis reveals mouse strain-dependent responses to acute ozone exposure associated with airway macrophage transcriptional activity
Acute ozone (O3) exposure is associated with multiple adverse cardiorespiratory outcomes,
the severity of which varies across individuals in human populations and inbred mouse …
the severity of which varies across individuals in human populations and inbred mouse …
[HTML][HTML] Quantitative NanoLC/NSI+-HRMS Method for 1,3-Butadiene Induced bis-N7-guanine DNA-DNA Cross-Links in Urine
1, 3-Butadiene (BD) is a common environmental and industrial chemical widely used in
plastic and rubber manufacturing and also present in cigarette smoke and automobile …
plastic and rubber manufacturing and also present in cigarette smoke and automobile …
Invited Perspective: Uneven Progress Addressing Population Variability in Human Health Risk Assessment
WA Chiu - Environmental Health Perspectives, 2024 - ehp.niehs.nih.gov
Concentration-Response Assessment. Geneva, Switzerland: WHO/ICPS. https://apps. who.
int/iris/handle/10665/43294 [accessed 21 August 2023]. 2. Bhat VS, Meek MEB, Valcke M …
int/iris/handle/10665/43294 [accessed 21 August 2023]. 2. Bhat VS, Meek MEB, Valcke M …