The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Perivascular spaces are important highways for fluid and solute transport in the brain
enabling efficient waste clearance during sleep. However, the underlying mechanisms …

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement
sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests …

In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …

Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term,
lack of sleep leads to impaired memory and attention; in the longer term, it produces …

Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa.
Sleep-inducing inflammatory molecules are activated by increased waking activity and …

The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …

Sleep is ubiquitous and essential, but its mechanisms remain unclear. Studies in animals
and humans have provided insights of sleep at vastly different spatiotemporal scales …