One of the major challenges in preclinical studies of alcohol abuse and dependence
remains the development of paradigms that will elicit high ethanol intake and mimic the …

Recreational use of alcohol is a social norm in many communities worldwide. Alcohol use in
moderation brings pleasure and may protect the cardiovascular system. However, excessive …

Anxiety disorders often co-occur with alcohol use disorders, but the mechanisms underlying
this comorbidity remain elusive. Previously, we reported that rats withdrawn from chronic …

Depression is a well-known risk factor for developing relapse drinking, but the neuronal
mechanisms underlying the interactions between depression and alcohol use disorders …

Identification of ethanol's (EtOH) primary molecular brain targets and determination of their
functional role is an ongoing, important quest. Pentameric ligand‐gated ion channels, that is …

Background Alcohol binge drinking in humans is thought to increase the risk for alcohol use
disorder (AUD). Unclear is whether drinking patterns (eg, bingelike or stable drinking) …

Although postsynaptic glycine receptors (GlyRs) as αβ heteromers attract considerable
research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in …

Over the past two decades, combustible cigarette smoking has slowly declined by nearly
11% in America; however, the use of electronic cigarettes has increased tremendously …

It is well accepted that ethanol is able to produce major health and economic problems
associated to its abuse. Because of its intoxicating and addictive properties, it is necessary …

The lateral habenula (LHb) is activated by a range of aversive states including those related
to alcohol withdrawal and has glycine receptors (GlyRs), a sensitive target of alcohol …