Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and
hypotheses on the key aspects of the evolution of life on earth in light of comparative …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …

Biochemistry and molecular biology rely on the recognition of structural complementarity
between molecules. Molecular interactions must be both quickly reversible, ie, tenuous, and …

Aminoacyl‐tRNA synthetases (AARSs) charge tRNA with their cognate amino acids. Many
other enzymes use amino acids as substrates, yet discrimination against noncognate amino …

Non-ribosomal peptide biosynthesis produces highly diverse natural products through a
complex cascade of enzymatic reactions that together function with high selectivity to …

Faithful translation of the genetic code during protein synthesis is fundamental to the growth,
development, and function of living organisms. Aminoacyl‐tRNA synthetases (AARSs) …

The apicomplexan parasites Cryptosporidium and Toxoplasma are serious threats to human
health. Cryptosporidiosis is a severe diarrheal disease in malnourished children and …