Recent advances in hyperthermia therapy‐based synergistic immunotherapy

M Chang, Z Hou, M Wang, C Li, J Lin - Advanced Materials, 2021 - Wiley Online Library
The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy
against malignant tumors. Nanomaterial‐based photothermal therapy (PTT) and magnetic …

mRNA vaccine era—mechanisms, drug platform and clinical prospection

S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

A DNA nanodevice-based vaccine for cancer immunotherapy

S Liu, Q Jiang, X Zhao, R Zhao, Y Wang, Y Wang… - Nature Materials, 2021 - nature.com
A major challenge in cancer vaccine therapy is the efficient delivery of antigens and
adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we …

The great immune escape: understanding the divergent immune response in breast cancer subtypes

SS Onkar, NM Carleton, PC Lucas, TC Bruno, AV Lee… - Cancer discovery, 2023 - AACR
Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

N Nagarsheth, MS Wicha, W Zou - Nature Reviews Immunology, 2017 - nature.com
The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

Cryomicroneedles for transdermal cell delivery

H Chang, SWT Chew, M Zheng, DCS Lio… - Nature Biomedical …, 2021 - nature.com
Cell therapies for the treatment of skin disorders could benefit from simple, safe and efficient
technology for the transdermal delivery of therapeutic cells. Conventional cell delivery by …

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Y Dai, C Xu, X Sun, X Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared
with normal tissue, the tumour microenvironment has some unique properties, such as …

Biomimetic nanotechnology toward personalized vaccines

J Zhou, AV Kroll, M Holay, RH Fang… - Advanced …, 2020 - Wiley Online Library
While traditional approaches for disease management in the era of modern medicine have
saved countless lives and enhanced patient well‐being, it is clear that there is significant …

Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

H Wang, AJ Najibi, MC Sobral, BR Seo, JY Lee… - Nature …, 2020 - nature.com
Poorly immunogenic tumors, including triple negative breast cancers (TNBCs), remain
resistant to current immunotherapies, due in part to the difficulty of reprogramming the highly …

A melanin-mediated cancer immunotherapy patch

Y Ye, C Wang, X Zhang, Q Hu, Y Zhang, Q Liu… - Science …, 2017 - science.org
Melanin is capable of transforming 99.9% of the absorbed sunlight energy into heat,
reducing the risk of skin cancer. We here develop a melanin-mediated cancer …