This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

The interactions between lipids and proteins are one of the most fundamental processes in
living organisms, responsible for critical cellular events ranging from replication, cell …

G-protein coupled receptors help regulate cellular function and communication, and are
targets of small molecule drug discovery efforts. Conventional techniques to probe these …

Biophysical techniques that enable the screening and identification of weak affinity
fragments against a target protein are at the heart of Fragment Based Drug Design …

Abstract Development of synthetic bioarchitectures to improve our understanding of
biological systems and produce biosynthetic models with new functions has attracted …

Several important drug targets, eg, ion channels and G protein–coupled receptors, are
extremely difficult to approach with current antibody technologies. To address these targets …

Pichia pastoris is a eukaryotic microorganism reputed for its ability to mass‐produce
recombinant proteins, including integral membrane proteins, for various applications. This …

Understanding the structure and function of key proteins located within biological
membranes is essential for fundamental knowledge and therapeutic applications. Robust …

Due to their unique properties, tunable size, and ability to provide a near native lipid
environment, nanodiscs have found widespread use for the structural and functional studies …

Attempts at substituting detergents with other surfactants for handling membrane proteins
(MPs) in aqueous solutions have a long history. They are based on three main incentives:(i) …