Tumour necrosis factor-α (TNFα) is a multifunctional cytokine belonging to a family of ligands
with an associated family of receptor proteins. The pleiotropic actions of TNF range from …

Tumour necrosis factor (TNF) exerts two main effects: a beneficial one as an anti-infection,
anti-tumour cytokine, and a detrimental one in the systemic inflammatory response …

The 60 kDa tumor necrosis factor receptor (TNF&) is regarded as the major signal
transducer of TNF-induced cellular responses, whereas the signal capacity and role of the …

Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmlc
domain of the human 75 kDa tumor necrosis factor receptor (TNFR2) that Is required for …

Tumor necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine triggering cell responses
through two distinct membrane receptors. Stimulation of leukocyte adhesion to the …

Tumor necrosis factor (TNF) is being utilized as an antineoplastic agent for the treatment of
patients with locally advanced solid tumors. However, its role in cancer therapy is debated …

To probe the ligand receptor interface, a number of point mutations were introduced in
selected regions of human tumor necrosis factor (TNF) alpha by site-directed mutagenesis …

Tumor necrosis factor receptor (TNFR) superfamily members can induce a context-
dependent apoptosis or cell activation. However, the mechanisms by which these opposing …

Tumor necrosis factor–α (TNF‐α) and TNF receptors (TNFR) are members of the growing
TNF ligand and receptor families that are involved in immune regulation. The present report …

Tumor necrosis factor α (TNFα) activates the stress-activated protein kinases (SAPKs, also
known as Jun nuclear kinases or JNKs) resulting in the stimulation of AP-1-dependent gene …