Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …
and influence cellular function via effects on membrane properties, and also by acting as a …
Formation, signaling and occurrence of specialized pro-resolving lipid mediators—what is the evidence so far?
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents
N Perico, M Cortinovis, F Suter… - The Lancet Infectious …, 2023 - thelancet.com
Summary COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of
symptom severity that requires varying amounts of care according to the different stages of …
symptom severity that requires varying amounts of care according to the different stages of …
[HTML][HTML] Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19
Y Zaid, E Dore, I Dubuc, AS Archambault… - Journal of Allergy and …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
lead to a variety of clinical outcomes, ranging from the absence of symptoms to severe acute …
lead to a variety of clinical outcomes, ranging from the absence of symptoms to severe acute …
[HTML][HTML] Mild COVID-19 imprints a long-term inflammatory eicosanoid-and chemokine memory in monocyte-derived macrophages
S Bohnacker, F Hartung, F Henkel, A Quaranta… - Mucosal …, 2022 - Elsevier
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of …
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …
Resolvin T-series reduce neutrophil extracellular traps
The newly identified 13-series (T-series) resolvins (RvTs) regulate phagocyte functions and
accelerate resolution of infectious inflammation. Because severe acute respiratory syndrome …
accelerate resolution of infectious inflammation. Because severe acute respiratory syndrome …
[HTML][HTML] Formation of lipoxins and resolvins in human leukocytes
Specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins are formed by
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing …
The COVID-19 pandemic has raised international awareness of the importance of rigorous
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …
The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
As coronavirus disease 2019 (COVID-19) persists, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) …
coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) …