Ca2+ channels and praziquantel: a view from the free world
JD Chan, M Zarowiecki, JS Marchant - Parasitology international, 2013 - Elsevier
Targeting the cellular Ca 2+ channels and pumps that underpin parasite Ca 2+ homeostasis
may realize novel antihelmintic agents. Indeed, the antischistosomal drug praziquantel …
may realize novel antihelmintic agents. Indeed, the antischistosomal drug praziquantel …
Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels
RF Stephens, W Guan, BS Zhorov… - Frontiers in …, 2015 - frontiersin.org
How nature discriminates sodium from calcium ions in eukaryotic channels has been difficult
to resolve because they contain four homologous, but markedly different repeat domains …
to resolve because they contain four homologous, but markedly different repeat domains …
Eukaryotic voltage-gated sodium channels: on their origins, asymmetries, losses, diversification and adaptations
JE Fux, A Mehta, J Moffat, JD Spafford - Frontiers in Physiology, 2018 - frontiersin.org
The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was
a limiting factor in the evolution of nervous systems. Two rounds of domain duplications …
a limiting factor in the evolution of nervous systems. Two rounds of domain duplications …
Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue
Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous
system, but little is known about when or how their unique properties and cellular roles …
system, but little is known about when or how their unique properties and cellular roles …
Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCav3. 2 activation
Y Yano, R Fukuoka, AD Maturana, SD Ohdachi… - Journal of Biological …, 2023 - ASBMB
Among the rare venomous mammals, the short-tailed shrew Blarina brevicauda has been
suggested to produce potent neurotoxins in its saliva to effectively capture prey. Several …
suggested to produce potent neurotoxins in its saliva to effectively capture prey. Several …
Divergent Ca2+/calmodulin feedback regulation of CaV1 and CaV2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and Bilateria
Ca V 1 and Ca V 2 voltage-gated calcium channels evolved from an ancestral Ca V 1/2
channel via gene duplication somewhere near the stem animal lineage. The divergence of …
channel via gene duplication somewhere near the stem animal lineage. The divergence of …
NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels
A Senatore, A Monteil, J van Minnen, AB Smit… - PLoS …, 2013 - journals.plos.org
NALCN is a member of the family of ion channels with four homologous, repeat domains that
include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene …
include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene …
The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1. 2 and Cav1. 3 channels
V Taiakina, AN Boone, J Fux, A Senatore… - PloS one, 2013 - journals.plos.org
NSCaTE is a short linear motif of (x W xxx (I or L) xxxx), composed of residues with a high
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …
T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) Outside the selectivity filter*♦
A Senatore, W Guan, AN Boone, JD Spafford - Journal of Biological …, 2014 - ASBMB
T-type (Ca v 3) channels are categorized as calcium channels, but invertebrate ones can be
highly sodium-selective channels. We illustrate that the snail LCa v 3 T-type channel …
highly sodium-selective channels. We illustrate that the snail LCa v 3 T-type channel …
Retinoic acid inhibits neuronal voltage-gated calcium channels
E de Hoog, MK Lukewich, GE Spencer - Cell Calcium, 2018 - Elsevier
Retinoic acid is the active metabolite of vitamin A and regulates several important cellular
processes by activating retinoic acid receptors (RAR) and retinoid X receptors (RXR). These …
processes by activating retinoic acid receptors (RAR) and retinoid X receptors (RXR). These …