Unique azolyl acylhydrazonyl hybridization of aloe emodins to access potential antibacterial agents

YX Wang, Z Deng, A Bibi, B Fang… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary A type of unique azole‐hybridized acylhydrazonyl aloe emodins
(AAEs) were developed as new antibacterial agents for combating bacterial infections …

Diisatin malonyldihydrazone complexes of high valent oxovanadium and oxozirconium ions for bio-chemical effectiveness and catalytic thiophene oxidation

MSS Adam, ALSI Alghanim, OS Abdel-Rahman… - Journal of Molecular …, 2024 - Elsevier
Bis-tridentate diisatin malonyldihydrazone ligand, H 2 Lhm, was prepared from the
condensed reaction of isatin with malonic dihydrazide. Its ligandated coordination features …

Expanding potential of quinoline hydrazide/hydrazone derivatives as anticancer agents

S Verma, S Lal, R Narang - Future Medicinal Chemistry, 2024 - Taylor & Francis
Globally, cancer is a major cause of mortality. According to a WHO report, 20 million new
cancer cases and 9.7 million deaths were estimated due to cancer in 2022. The use of …

Preferential inhibition of α-amylase by cinnamaldehyde-based hydrazones: A comparative study

C Vashisth, N Raghav - International Journal of Biological Macromolecules, 2024 - Elsevier
The escalating issue of obesity and related health conditions, including diabetes mellitus
and coronary heart disease, necessitates the development of digestive enzyme inhibitors …

[HTML][HTML] Synthesis, antitumor Activity, antimicrobial evaluation and molecular docking studies of some Hydrazone, 1, 3, 4-Oxadiazole, 1, 2, 4-Triazole and pyrazole …

AR Farghaly, SA Ahmed, KS Ismail, D Ibrahim… - Results in …, 2024 - Elsevier
In this study, we synthesized a number of new intriguing azoles bearing nicotinoyl moiety,
their antimicrobial and antitumor activities were investigated as well. We succeeded to …

Synthesis of novel 1, 2, 3-triazole-tethered N-acyl hydrazones as a new class of carbonic anhydrase II inhibitors: In vitro and in silico potentials

N Fatima, A Saeed, S Ullah, SA Halim, A Khan… - Bioorganic …, 2024 - Elsevier
Abstract Carbonic anhydrase II (CA II) is crucial for maintaining homeostasis in several
processes, including respiration, lipogenesis, gluconeogenesis, calcification, bone …

Substituent effect on the chemical and biological properties of diisatin dihydrazone Schiff bases: DFT and docking studies

MSS Adam, ZHA Al-Ateya, MM Makhlouf… - … Biology and Chemistry, 2024 - Elsevier
According to the considered role of lipophilicity-hydrophobicity on organic Schiff base
hydrazones, different substituents of phenyl, ethyl, and methyl groups were inserted in the …

Exploring highly selective polymethoxy fenamate isosteres as novel anti-prostate cancer agents: Synthesis, biological activity, molecular docking, molecular dynamics …

FS Tokalı, H Şenol, Ş Ateşoğlu, P Tokalı… - Journal of Molecular …, 2025 - Elsevier
In this study, we synthesized and characterized sixteen new polymethoxy-substituted
hydrazone derivatives. These compounds were evaluated for their in vitro cytotoxic activity …

Synthesis of Cu (II) and Zn (II) complexes of a quinoline based flexible amide receptor as fluorescent probe for dihydrogen phosphate and hydrogen sulphate and their …

S Dey, S Ghosh, A Das, RN Yadav, R Chakrabarty… - Journal of …, 2024 - Springer
A novel 8-hydroxy quinoline-derived amide receptor, in conjunction with its Cu (II) and Zn (II)
complexes, has been strategically developed to function as remarkably efficient fluorescent …

A review of hydrazide-hydrazone metal complexes' antitumor potential

N Ribeiro, I Correia - Frontiers in Chemical Biology, 2024 - frontiersin.org
Cancer inflicts a tremendous burden on modern society, and more effective and selective
treatments need to be developed. Metallodrugs have been extensively explored as …