[PDF][PDF] The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019—results from a systematic review and meta-analysis

M Bauer, H Gerlach, T Vogelmann, F Preissing… - Critical Care, 2020 - Springer
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The
heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19

J Thachil, N Tang, S Gando, A Falanga… - Journal of Thrombosis …, 2020 - jthjournal.org
The novel corona virus infection (now classified as COVID-19), first identified in December
2019 in Wuhan, China, has contributed to significant mortality in several countries with the …

The SOFA score—development, utility and challenges of accurate assessment in clinical trials

S Lambden, PF Laterre, MM Levy, B Francois - Critical Care, 2019 - Springer
Abstract The Sequential Organ Failure Assessment or SOFA score was developed to assess
the acute morbidity of critical illness at a population level and has been widely validated as a …

Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the …

A Padmanabhan, L Connelly‐Smith… - Journal of clinical …, 2019 - Wiley Online Library
ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating and categorizing …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

Sepsis and septic shock

M Cecconi, L Evans, M Levy, A Rhodes - The Lancet, 2018 - thelancet.com
Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

C Gutmann, K Takov, SA Burnap, B Singh, H Ali… - Nature …, 2021 - nature.com
Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with
coronavirus disease 2019 (COVID-19). We obtained blood samples (n= 474) from …

Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA …

G Hernández, GA Ospina-Tascón, LP Damiani… - Jama, 2019 - jamanetwork.com
Importance Abnormal peripheral perfusion after septic shock resuscitation has been
associated with organ dysfunction and mortality. The potential role of the clinical assessment …