Pathogenesis of systemic sclerosis
D Pattanaik, M Brown, BC Postlethwaite… - Frontiers in …, 2015 - frontiersin.org
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …
Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of human fibrotic diseases
S Piera-Velazquez, FA Mendoza… - Journal of clinical …, 2016 - mdpi.com
Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
S Pavlides, D Whitaker-Menezes, R Castello-Cros… - Cell cycle, 2009 - Taylor & Francis
Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …
Cellular interactions in the pathogenesis of interstitial lung diseases
G Bagnato, S Harari - European Respiratory Review, 2015 - Eur Respiratory Soc
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …
conditions that share similar clinical, radiological and pathological manifestations, despite …
Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis
Extracellular matrix (ECM) homeostasis is essential for normal tissue function, and its
disruption by iatrogenic injury, trauma, or disease results in fibrosis. Skin ECM homeostasis …
disruption by iatrogenic injury, trauma, or disease results in fibrosis. Skin ECM homeostasis …
Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms
F Sotgia, UE Martinez-Outschoorn… - Annual Review of …, 2012 - annualreviews.org
Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …
[HTML][HTML] Strategies for anti-fibrotic therapies
J Rosenbloom, FA Mendoza, SA Jimenez - Biochimica et Biophysica Acta …, 2013 - Elsevier
The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …
Human fibrotic diseases: current challenges in fibrosis research
J Rosenbloom, E Macarak, S Piera-Velazquez… - Fibrosis: methods and …, 2017 - Springer
Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …
number of affected individuals, the incomplete knowledge of the fibrotic process …
Transforming growth factor β as a therapeutic target in systemic sclerosis
Transforming growth factor β (TGF-β) is a pleiotropic cytokine with vital homeostatic
functions. Aberrant TGF-β expression is implicated in the pathogenesis of fibrosis in …
functions. Aberrant TGF-β expression is implicated in the pathogenesis of fibrosis in …
The living scar–cardiac fibroblasts and the injured heart
Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …
contributing to the maintenance of structural and mechanical integrity following heart injury …