Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …

Extracellular matrix (ECM) homeostasis is essential for normal tissue function, and its
disruption by iatrogenic injury, trauma, or disease results in fibrosis. Skin ECM homeostasis …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …

Transforming growth factor β (TGF-β) is a pleiotropic cytokine with vital homeostatic
functions. Aberrant TGF-β expression is implicated in the pathogenesis of fibrosis in …

Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …