Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2024 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

MicroRNA: a linking between astrocyte dysfunction, mild cognitive impairment, and neurodegenerative diseases

AE Ramírez, N Gil-Jaramillo, MA Tapias… - Life, 2022 - mdpi.com
Simple Summary Neurodegenerative diseases are complex neurological disorders with a
high incidence worldwide in older people, increasing hospital visits and requiring expensive …

Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway …

G Shi, L Liu, Y Cao, G Ma, Y Zhu, J Xu, X Zhang… - Journal of …, 2023 - Springer
Background Neuroinflammation is one of the most important pathogeneses in secondary
brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming …

Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury

C Zhou, S Li, N Qiu, P Sun, MH Hamblin… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
The diffuse axonal damage in white matter and neuronal loss, along with excessive
neuroinflammation, hinder long-term functional recovery after traumatic brain injury (TBI) …

Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury

C Zhou, P Sun, MH Hamblin, KJ Yin - Journal of Neuroinflammation, 2022 - Springer
Background The long-term functional recovery of traumatic brain injury (TBI) is hampered by
pathological events, such as parenchymal neuroinflammation, neuronal death, and white …

[HTML][HTML] APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K/AKT pathway

X He, M Wu, L Chen, M Liu, X Hu, Y Meng… - Biomedicine & …, 2024 - Elsevier
Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond
thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered …

Tilianin improves cognition in a vascular dementia rodent model by targeting miR-193b-3p/CaM-and miR-152-3p/CaMKIIα-mediated inflammatory and apoptotic …

T Sun, L Tan, M Liu, L Zeng, K Zhao, Z Cai… - Frontiers in …, 2023 - frontiersin.org
Introduction Although vascular dementia (VaD) is the second most prevalent form of
dementia, there is currently a lack of effective treatments. Tilianin, isolated from the …

Intranasal administration nanosystems for brain-targeted drug delivery

Y Jiang, X Pan, T Yu, H Wang - Nano Research, 2023 - Springer
The existence of the blood-brain barrier (BBB) restricts the entry of drugs from the circulation
into the central nervous system (CNS), which severely affects the treatment of neurological …

[HTML][HTML] Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma

Y Kong, Y Luo, S Zheng, J Yang, D Zhang, Y Zhao… - Cancer Research, 2023 - AACR
Circular RNAs (circRNA) contribute to cancer stemness, proliferation, and metastasis. The
biogenesis of circRNAs can be impacted by the genetic landscape of tumors. Herein, we …

Gain‐of‐function of progesterone receptor membrane component 2 ameliorates ischemic brain injury

C Zhou, T Zhu, W Ni, H Zhou, J Song… - CNS Neuroscience …, 2023 - Wiley Online Library
Objective Progesterone receptor membrane component 2 (PGRMC2) belongs to the
membrane‐associated progesterone receptor family, which regulates multiple …