Generating the barriers that protect our inner surfaces from bacteria and other challenges
requires large glycoproteins called mucins. These come in two types, gel-forming and …

The composition and organization of the cell walls from Saccharomyces cerevisiae, Candida
albicans, Aspergillus fumigatus, Schizosaccharomyces pombe, Neurospora crassa, and …

The wall gives a Saccharomyces cerevisiae cell its osmotic integrity; defines cell shape
during budding growth, mating, sporulation, and pseudohypha formation; and presents …

Mucosal surfaces line our body cavities and provide the interaction surface between
commensal and pathogenic microbiota and the host. The barrier function of the mucosal …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

Filamentous growth is a nutrient-regulated growth response that occurs in many fungal
species. In pathogens, filamentous growth is critical for host–cell attachment, invasion into …

Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …

In their natural habitats, unicellular fungal microbes are exposed to a myriad of mechanical
cues such as shear forces from fluid flow, osmotic changes, and contact forces arising from …

Surface recognition and penetration are among the most critical plant infection processes in
foliar pathogens. In Magnaporthe oryzae, the Pmk1 MAP kinase regulates appressorium …