Multi-cellular organisms such as humans contain hundreds of cell types that share the same
genetic information (DNA sequences), and yet have different cellular traits and functions …

The current understanding of how specific distributions of histone post-translational
modifications (PTMs) are achieved throughout the chromatin remains incomplete. This …

For some inducible genes, the rate and molecular mechanism of transcriptional activation
depend on the prior experiences of the cell. This phenomenon, called epigenetic …

H3K4 trimethylation (H3K4me3) is a conserved histone modification catalyzed by histone
methyltransferase Set1, and its dysregulation is associated with pathologies. Here, we show …

The interconnections between co-transcriptional regulation, chromatin environment, and
transcriptional output remain poorly understood. Here, we investigate the mechanism …

Phosphorylation is a major constituent of the CTD code, which describes the set of post-
translational modifications on 52 repeats of a YSPTSPS consensus heptad that orchestrates …

Abstract Mono-, di-, and trimethylation of histone H3 lysine 4 (H3K4me1/2/3) are associated
with transcription, yet it remains controversial whether H3K4me1/2/3 promote or result from …

Postintegration transcriptional silencing of HIV-1 leads to the establishment of a pool of
latently infected cells. In these cells, mechanisms controlling RNA Polymerase II (RNAPII) …

Fusarium graminearum produces the mycotoxin deoxynivalenol (DON) which promotes its
expansion during infection on its plant host wheat. Conditional expression of DON …

The human genome encodes large numbers of non-coding RNAs, including divergent
antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by …