GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues
Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …
Molecular basis of SARS-CoV-2 infection and rational design of potential antiviral agents: modeling and simulation approaches
The emergence in late 2019 of the coronavirus SARS-CoV-2 has resulted in the
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …
Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer
Ferroptosis, an iron-dependent regulated cell death process driven by excessive lipid
peroxides, can enhance cancer vulnerability to chemotherapy, targeted therapy and …
peroxides, can enhance cancer vulnerability to chemotherapy, targeted therapy and …
The Chemical Reactivity of Membrane Lipids
G Duché, JM Sanderson - Chemical Reviews, 2024 - ACS Publications
It is well-known that aqueous dispersions of phospholipids spontaneously assemble into
bilayer structures. These structures have numerous applications across chemistry and …
bilayer structures. These structures have numerous applications across chemistry and …
The contribution of lipid peroxidation to membrane permeability in electropermeabilization: A molecular dynamics study
L Rems, M Viano, MA Kasimova, D Miklavčič… - Bioelectrochemistry, 2019 - Elsevier
Electroporation or electropermeabilization is a technique that enables transient increase in
the cell membrane permeability by exposing cells to pulsed electric field. However, the …
the cell membrane permeability by exposing cells to pulsed electric field. However, the …
Antioxidant and membrane binding properties of serotonin protect lipids from oxidation
S Azouzi, H Santuz, S Morandat, C Pereira, F Côté… - Biophysical journal, 2017 - cell.com
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is a well-known neurotransmitter that is
involved in a growing number of functions in peripheral tissues. Recent studies have shown …
involved in a growing number of functions in peripheral tissues. Recent studies have shown …
Molecular dynamics simulations of the effects of lipid oxidation on the permeability of cell membranes
The formation of transient pores in their membranes is a well-known mechanism of
permeabilization of cells exposed to high-intensity electric pulses. However, the formation of …
permeabilization of cells exposed to high-intensity electric pulses. However, the formation of …
[HTML][HTML] Antioxidant activity of highly hydroxylated fullerene C60 and its interactions with the analogue of α-tocopherol
Polyhydroxylated fullerenes (fullerenols) are excellent free radical scavengers. Despite the
large number of reports on their reactions with reactive oxygen species, there is no report on …
large number of reports on their reactions with reactive oxygen species, there is no report on …
Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes
Vitamins E, C and polyphenols (flavonoids and non-flavonoids) are major natural
antioxidants capable of preventing damage generated by oxidative stress. Here we show …
antioxidants capable of preventing damage generated by oxidative stress. Here we show …
Understanding membrane remodelling initiated by photosensitized lipid oxidation
TM Tsubone, MS Baptista, R Itri - Biophysical chemistry, 2019 - Elsevier
In this review, we describe how photooxidation changes membrane properties that can
ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the …
ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the …