The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab
genes in the human genome, and a number of Rab GTPases are conserved from yeast to …

The mevalonate pathway for cholesterol biosynthesis and protein prenylation has been
implicated in various aspects of tumor development and progression. Certain classes of …

Two key events of intracellular transport and membrane trafficking in eukaryotic cells, the
formation of transport vesicles and their specific delivery to target membranes, are controlled …

Rab GTPases require special machinery for protein prenylation, which include Rab escort
protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab …

Aberrant protein tyrosine phosphorylation resulting from the altered activity of protein
tyrosine phosphatases (PTPs) is increasingly being implicated in the genesis and …

Griscelli syndrome (GS) is a rare autosomal recessive disorder caused by mutations in
either the myosin VA (GS1), RAB27A (GS2) or melanophilin (GS3) genes. The three GS …

Prenylated Rab proteins exist in the cytosol as soluble, high-affinity complexes with GDI that
need to be disrupted for membrane attachment and targeting of Rab proteins. The …

Small GTPases of the Rab family regulate membrane transport pathways. More than 50
mammalian Rab proteins are known, many with transport step-specific localisation. Rabs …

H ermansky–P udlak syndrome (HPS) is an autosomal recessive and genetically
heterogeneous disorder characterized by oculocutaneous albinism, bleeding tendency, and …

Rab proteins are members of the Ras superfamily of GTPases and are key regulators of
intracellular vesicular transport. They undergo a cycle of GTPase activity, and this activity is …