The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Abstract Development of the mammalian embryo begins with formation of the totipotent
zygote during fertilization. This initial cell is able to give rise to every embryonic tissue of the …

Organoids are lumen‐containing multicellular structures that recapitulate key features of the
organs, and are increasingly used in models of disease, drug testing, and regenerative …

INTRODUCTION Gastrulation is a landmark event in development that involves a complex
series of molecular, physical, and energetic remodeling transitions in early embryogenesis …

During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …

BACKGROUND The embryo implantation process is crucial for the correct establishment
and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to …

Research using human embryos and embryoids has expanded in recent years due to
technological advances. Surveying laws and guidelines among the top research and …

Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

The “14‐day rule”—broadly construed—is used in science policy and regulation to limit
research on human embryos to a maximum period of 14 days after their creation or to the …

Research in developmental biology has been recently enriched by a multitude of in vitro
models recapitulating key milestones of mammalian embryogenesis. These models obviate …