Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Inflammasomes are intracellular complexes involved in the innate immunity that convert
proIL‐1β and proIL‐18 to mature forms and initiate pyroptosis via cleaving procaspase‐1 …

Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for
decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It …

In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …