To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living
organisms–survival factor or ruthless killer. It has long been known that Ca2+ signals govern …

Photodynamic therapy (PDT) is a recently developed anticancer modality utilizing the
generation of singlet oxygen and other reactive oxygen species, through visible light …

Collagen VI is an extracellular matrix protein that forms a microfilamentous network in
skeletal muscles and other organs,,. Inherited mutations in genes encoding collagen VI in …

Abstract Calcium ions (Ca 2+) and the complex regulatory system governed by Ca 2+
signaling have been described to be of crucial importance in numerous aspects related to …

Natural products (NPs) inspire the design and synthesis of novel biologically relevant
chemical matter, for instance through biology‐oriented synthesis (BIOS). However, BIOS is …

The biology of the mitochondrial electron transport chain is summarized. Our approach to
the mechanism of uncouplers, inhibitors, and toxins is based on electron transfer (ET) and …

We studied the effects of the divalent cation ionophore A23187 on apoptotic signaling in
MH1C1 cells. Addition of A23187 caused a fast rise of cytosolic Ca 2+([Ca 2+] c), which …

Mitochondrial fission ensures organelle inheritance during cell division and participates in
apoptosis. The fission protein hFis1 triggers caspase-dependent cell death, by causing the …

Drugs able to inhibit both cyclooxygenases (COX-1 and COX-2) and 5-lipoxygenase (5-
LOX)(dual acting anti-inflammatory drugs) have been designed in order to obtain …

Abstract Cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LOX) are key enzymes involved in
arachidonic acid metabolism. Their products, prostaglandins and leukotrienes, are involved …