Drug resistance in human helminths: current situation and lessons from livestock
S Geerts, B Gryseels - Clinical microbiology reviews, 2000 - Am Soc Microbiol
In this review the available reports on drug resistance in human helminths, particularly
hookworms and schistosomes, are critically analyzed. The experiences with helminths of …
hookworms and schistosomes, are critically analyzed. The experiences with helminths of …
Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis—a meta-analysis of comparative and non-comparative clinical trials
J Zwang, PL Olliaro - PLoS neglected tropical diseases, 2014 - journals.plos.org
Background Extensive use of praziquantel for treatment and control of schistosomiasis
requires a comprehensive understanding of efficacy and safety of various doses for different …
requires a comprehensive understanding of efficacy and safety of various doses for different …
[PDF][PDF] Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers.
M Ismail, S Botros, A Metwally, S William… - The American journal …, 1999 - researchgate.net
Recent evidence suggest that resistance to praziquantel (PZQ) may be developing. This
would not be surprising in countries like Egypt where the drug has been used aggressively …
would not be surprising in countries like Egypt where the drug has been used aggressively …
Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel.
M Ismail, A Metwally, A Farghaly, J Bruce… - The American journal …, 1996 - europepmc.org
To determine if resistance/tolerance to the antischistosomal drug praziquantel (PZQ) is
appearing in Egyptian villages within the Nile delta region, where it has been used …
appearing in Egyptian villages within the Nile delta region, where it has been used …
Efficacy and safety of praziquantel 40 mg/kg in preschool-aged and school-aged children: a meta-analysis
J Zwang, P Olliaro - Parasites & vectors, 2017 - Springer
Background Children carry most of the schistosomiasis burden. While school-aged children
are the principal target group of preventive chemotherapy with praziquantel, limited …
are the principal target group of preventive chemotherapy with praziquantel, limited …
The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)
P Olliaro, P Delgado-Romero… - Journal of Antimicrobial …, 2014 - academic.oup.com
Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely
distributed since 2006 through 'preventive chemotherapy'programmes to school-aged …
distributed since 2006 through 'preventive chemotherapy'programmes to school-aged …
Anthelmintics: a comparative review of their clinical pharmacology
N de Silva, H Guyatt, D Bundy - Drugs, 1997 - Springer
Virtually all the important helminth infections in humans can be treated with one of 5
anthelmintics currently in use: albendazole, mebendazole, diethylcarbamazine, ivermectin …
anthelmintics currently in use: albendazole, mebendazole, diethylcarbamazine, ivermectin …
Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental …
G Zdesenko, F Mutapi - PLoS neglected tropical diseases, 2020 - journals.plos.org
Schistosomiasis control is heavily reliant on the drug praziquantel (PZQ), which is used as
preventive chemotherapy as part of national helminth control strategies. Given the heavy …
preventive chemotherapy as part of national helminth control strategies. Given the heavy …
Drugs for treating Schistosoma mansoni infection
A Danso‐Appiah, PL Olliaro… - Cochrane Database …, 2013 - cochranelibrary.com
Background Schistosoma mansoni is a parasitic infection common in the tropics and sub‐
tropics. Chronic and advanced disease includes abdominal pain, diarrhoea, blood in the …
tropics. Chronic and advanced disease includes abdominal pain, diarrhoea, blood in the …
Population pharmacokinetics and pharmacodynamics of praziquantel in Ugandan children with intestinal schistosomiasis: higher dosages are required for maximal …
AL Bustinduy, D Waterhouse, JC de Sousa-Figueiredo… - MBio, 2016 - Am Soc Microbiol
Each year, millions of African children receive praziquantel (PZQ) by mass drug
administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body …
administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body …