Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development

AK Jugran, S Rawat, HP Devkota, ID Bhatt… - Phytotherapy …, 2021 - Wiley Online Library
Diabetes is a disease of serious concern faced by the health care industry today. Primary
diabetes mellitus and its complications are still costly to manage with modern drugs …

Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism

M Luo, Y Zheng, S Tang, L Gu, Y Zhu, R Ying… - Frontiers in …, 2023 - frontiersin.org
Background: The incidence of glycolipid metabolic diseases is extremely high worldwide,
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …

Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

M Ben Salem, R Ben Abdallah Kolsi, R Dhouibi… - … and alternative medicine, 2017 - Springer
Background Diabetes mellitus (DM) is associated with hyperglycemia, inflammatory
disorders and abnormal lipid profiles, currently the extracts from leaves of cynara scolymus …

Ethnomedicinal study of medicinal plants used by Mizo tribes in Champhai district of Mizoram, India

TBC Laldingliani, NM Thangjam… - Journal of Ethnobiology …, 2022 - Springer
Background Medicinal plants have been used countless times for curing diseases mainly in
developing countries. They are easily available with little to no side effects when compared …

Herbal Medicines Targeting the Improved β‐Cell Functions and β‐Cell Regeneration for the Management of Diabetes Mellitus

ASD Wickramasinghe, P Kalansuriya… - Evidence‐Based …, 2021 - Wiley Online Library
There is an increasing trend of investigating natural bioactive compounds targeting
pancreatic β‐cells for the prevention/treatment of diabetes mellitus (DM). With the …

[HTML][HTML] The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar …

GI Edo, AN Jikah, FO Onoharigho… - Food Chemistry …, 2024 - Elsevier
Abstracts Vernonia amygdalina possess specialized metabolites which have been shown to
minimize the risk of human diseases. This study was aimed to evaluate the effect of V …

Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity

RM Hussein, DM Sawy, MA Kandeil, HS Farghaly - Life Sciences, 2021 - Elsevier
Background and aims The normal functioning of Kelch-like ECH-associated protein-1
(Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) complex is necessary for the …

Plant polyphenols mechanisms of action on insulin resistance and against the loss of pancreatic beta cells

C Papuc, GV Goran, CN Predescu… - Critical reviews in …, 2021 - Taylor & Francis
Diabetes mellitus describes a group of metabolic disorders characterized by a prolonged
period hyperglycemia with long-lasting detrimental effects on the cardiovascular and …

In vitro anticoagulant effect of Crassocephalum crepidioides leaf methanol extract and fractions on human blood

OO Ayodele, FD Onajobi, O Osoniyi - Journal of experimental …, 2019 - Taylor & Francis
Background Blood coagulation is a rapid and efficient process that produces clot formation
which requires regulation. A derangement of blood coagulation is a feature of many disease …

Regeneration of pancreatic beta cells by modulation of molecular targets using plant-derived compounds: pharmacological mechanisms and clinical potential

CN Kimani, H Reuter, SH Kotzé, CJF Muller - Current Issues in Molecular …, 2023 - mdpi.com
Type 2 diabetes (T2D) is characterized by pancreatic beta-cell dysfunction, increased cell
death and loss of beta-cell mass despite chronic treatment. Consequently, there has been …