It is now little disputed that most if not all cancer cells express antigens that can be
recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti …

Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-MET) signaling
is involved in complex cellular programs that are important for embryonic development and …

Metformin is the most widely used antidiabetic drug because of its proven efficacy and
limited secondary effects. Interestingly, recent studies have reported that metformin can …

In melanoma, as well as in other solid tumors, the cells within a given tumor exhibit strong
morphological, functional and molecular heterogeneity that might reflect the existence of …

UV radiation is an important etiologic factor for skin cancer, including melanoma.
Constitutive pigmentation and the ability to tan are considered the main photoprotective …

The skin is the largest organ of the body and protects the organism against external
physical, chemical and biological insults, such as wounding, ultraviolet radiation and micro …

Maternal diabetes adversely affects preimplantation embryo development and pregnancy
outcomes. The objective of this study was to determine whether diabetes has an impact at …

Generalized vitiligo is an acquired disorder in which white patches of skin and overlying hair
result from autoimmune loss of melanocytes from involved areas. The autoimmune …

Apoptosis and senescence are cellular failsafe programs that counteract excessive
mitogenic signaling observed in cancer cells. Melanoma is known for its notorious …

Melanocytes undergo extensive genetic changes during transformation into aggressive
melanomas. These changes deregulate genes whose aberrant activity promotes the …