Bicarbonate is one of the major anions in mammalian tissues and fluids, is utilized by
various exchangers to transport other ions and organic substrates across cell membranes …

Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

The solute carrier 26 family member A9 (SLC26A9) is an epithelial anion transporter that is
assumed to contribute to airway chloride secretion and surface hydration. Whether …

Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing
loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic …

Asthmatics have elevated levels of IL-17A compared to healthy controls. IL-17A is likely to
contribute to reduced corticosteroid sensitivity of human airway epithelium. Here, we aimed …

Fine control over chloride homeostasis in the lung is required to maintain membrane
excitability, transepithelial transport as well as intra-and extracellular ion and water …

Abstract Solute carrier family 26 (SLC26) is a family of functionally diverse anion
transporters found in all kingdoms of life. Anions transported by SLC26 proteins include …

Abstract The small GTPase RhoA and its downstream effectors are critical regulators in the
pathophysiological processes of asthma. The underlying mechanism, however, remains …

Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane
Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate …

Variants in SLC26A4 (pendrin) are the most common reasons for genetic hearing loss and
vestibular dysfunction in East Asians. In patients with Pendred syndrome and DFNB4 …