[HTML][HTML] In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
Microglial NLRP3 inflammasome activation in multiple sclerosis
Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …
New targets and therapeutics for neuroprotection, remyelination and repair in multiple sclerosis
P Villoslada, L Steinman - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction Immunotherapies for multiple sclerosis (MS) significantly decrease the risk of
new relapses. However, the chronic compartmentalized inflammation and …
new relapses. However, the chronic compartmentalized inflammation and …
The p53 family in brain disease
M Agostini, G Melino, F Bernassola - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …
roles in both biological and pathological processes, including cancer and neural …
Neural stem cell-based regenerative approaches for the treatment of multiple sclerosis
J Xiao, R Yang, S Biswas, Y Zhu, X Qin, M Zhang… - Molecular …, 2018 - Springer
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory, and demyelinating disorder
of the central nervous system (CNS), which ultimately leads to axonal loss and permanent …
of the central nervous system (CNS), which ultimately leads to axonal loss and permanent …
Viruses and multiple sclerosis: from mechanisms and pathways to translational research opportunities
AFA Mentis, E Dardiotis, N Grigoriadis, E Petinaki… - Molecular …, 2017 - Springer
Viruses are directly or indirectly implicated in multiple sclerosis (MS). Here, we review the
evidence on the virus-related pathophysiology of MS, introduce common experimental …
evidence on the virus-related pathophysiology of MS, introduce common experimental …
The post-GWAS era: how to validate the contribution of gene variants in lupus
AJ Fike, I Elcheva, ZSM Rahman - Current rheumatology reports, 2019 - Springer
Abstract Purpose of Review Systemic lupus erythematosus (SLE) is a complex autoimmune
disease with strong genetic associations. Here, we provide an update on recent …
disease with strong genetic associations. Here, we provide an update on recent …
[HTML][HTML] Melanoma-derived iPCCs show differential tumorigenicity and therapy response
M Bernhardt, D Novak, Y Assenov, E Orouji, N Knappe… - Stem Cell Reports, 2017 - cell.com
A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is
present in 45%–60% of patients and acts as a key driver in melanoma. Shortly after therapy …
present in 45%–60% of patients and acts as a key driver in melanoma. Shortly after therapy …
[HTML][HTML] Advances in monitoring cell-based therapies with magnetic resonance imaging: future perspectives
Cell-based therapies are currently being developed for applications in both regenerative
medicine and in oncology. Preclinical, translational, and clinical research on cell-based …
medicine and in oncology. Preclinical, translational, and clinical research on cell-based …
MS‐Driven Metabolic Alterations Are Recapitulated in iPSC‐Derived Astrocytes
B Ghirotto, DF Oliveira, M Cipelli, PJ Basso… - Annals of …, 2022 - Wiley Online Library
Objective Astrocytes play a significant role in the pathology of multiple sclerosis (MS).
Nevertheless, for ethical reasons, most studies in these cells were performed using the …
Nevertheless, for ethical reasons, most studies in these cells were performed using the …