Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …

Introduction Immunotherapies for multiple sclerosis (MS) significantly decrease the risk of
new relapses. However, the chronic compartmentalized inflammation and …

Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory, and demyelinating disorder
of the central nervous system (CNS), which ultimately leads to axonal loss and permanent …

Viruses are directly or indirectly implicated in multiple sclerosis (MS). Here, we review the
evidence on the virus-related pathophysiology of MS, introduce common experimental …

Abstract Purpose of Review Systemic lupus erythematosus (SLE) is a complex autoimmune
disease with strong genetic associations. Here, we provide an update on recent …

A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is
present in 45%–60% of patients and acts as a key driver in melanoma. Shortly after therapy …

Cell-based therapies are currently being developed for applications in both regenerative
medicine and in oncology. Preclinical, translational, and clinical research on cell-based …

Objective Astrocytes play a significant role in the pathology of multiple sclerosis (MS).
Nevertheless, for ethical reasons, most studies in these cells were performed using the …