Conspectus Atropisomerism is a conformational chirality that occurs when there is hindered
rotation about a σ-bond. While atropisomerism is exemplified by biaryls, it is observed in …

The gene encoding the receptor-tyrosine kinase RET was first discovered more than three
decades ago, and activating RET rearrangements and mutations have since been identified …

Precision oncology informed by genomic information has evolved in leaps and bounds over
the last decade. Although non-small cell lung cancer (NSCLC) has moved to center-stage as …

Following the identification of the BCR-ABL1 (Breakpoint Cluster Region-ABelson murine
Leukemia) fusion in chronic myelogenous leukemia, gene fusions generating chimeric …

Abstract Treatment of cancer metastasis has been largely ineffective. It is paramount to
understand the mechanisms underlying the metastatic process, of which the tumor …

Recent clinical trials have shown several multi-target tyrosine kinase inhibitors (TKIs) to be
effective in the treatment of osteosarcoma. However, these TKIs have a number of targets …

RET receptor tyrosine kinase is activated in various cancers (lung, thyroid, colon and
pancreatic, among others) through oncogenic fusions or gain-of-function single-nucleotide …

The discoveries of cancer research have been translated into the clinical management of
lung cancer patients. So far, the approach of targeted therapy that is directed towards certain …

Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-
cells and can occur either as sporadic or as hereditary diseases in the context of familial …

RET is a transmembrane receptor protein-tyrosine kinase that is required for the
development of the nervous system and several other tissues. The mechanism of activation …