In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed
and, as a result, are subject to meiotic sex chromosome inactivation (MSCI). MSCI is …

Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis
and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy …

As phosphorus is one of the most limiting nutrients in many natural and agricultural
ecosystems, plants have evolved strategies that cope with its scarcity. Genetic approaches …

During meiotic prophase I, spermatocytes must balance transcriptional activation with
homologous recombination and chromosome synapsis, biological processes requiring …

Gene regulation in the germline ensures the production of high-quality gametes, long-term
maintenance of the species and speciation. Male germline transcriptomes undergo dynamic …

The switch from mitosis to meiosis ensures the successive formation of gametes. However, it
remains unclear how meiotic initiation occurs within the context of chromatin. Recent studies …

In brief The testis-specific transcription factor, TCFL5, expressed in pachytene
spermatocytes regulates the meiotic gene expression program in collaboration with the …

Transposable elements (TEs) initially attracted attention because they comprise a major
portion of the genomic sequences in plants and animals. TEs may jump around the genome …

Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror
gene expression programs of the next generation. However, it remains largely unknown how …

Retinoic acid (RA) is the proposed mammalian 'meiosis inducing substance'. However,
evidence for this role comes from studies in the fetal ovary, where germ cell differentiation …