Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Abstract Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2 and has spread
across the globe. SARS‐CoV‐2 is a highly infectious virus with no vaccine or antiviral …

Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …

The past decade has seen an explosion in the field of in vitro disease modelling, in
particular the development of organoids. These self-organizing tissues derived from stem …

Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …

The human cerebral cortex possesses distinct structural and functional features that are not
found in the lower species traditionally used to model brain development and disease …

Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or
pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in …

Viruses regulate host metabolic networks to improve their survival. The molecules that are
responsive to viral infection and regulate such metabolic changes are hardly known, but are …

Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers.
Recently, non-alcoholic steatohepatitis (NASH) has been recognized as a major HCC …