Mitochondria with structural and functional integrity are essential for maintaining
mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Background Mitochondrial dysfunction results in an imbalance between energy supply and
demand in a failing heart. An innovative therapy that targets the intracellular bioenergetics …

Members of the PGC‐1 family of coactivators have been revealed as key players in the
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …

Aims Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a
prevalent and complex condition leading to left ventricle thickening and heart dysfunction …

The role of selenium nanoparticles (Se-NPs) in the mitigation of high-temperature (HT)
stress in crops is not known. The uptake, toxicity and physiological and biological effects of …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

Although the concept of energy starvation in the failing heart was proposed decades ago,
still very little is known about the origin of energetic failure. Recent advances in molecular …

Background High temperature is a major abiotic stress that limits wheat (Triticum aestivum
L.) productivity. Variation in levels of a wide range of lipids, including stress-related …

Heart failure is a pressing public health problem with no curative treatment currently
available. The existing therapies provide symptomatic relief, but are unable to reverse …